E-AB-40578
CXCL12/SDF1 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- E-AB-40578
- Additional Names:
- SDF-1,Cxcl12
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Rat CXCL12 protein expressed by E.coli.
- Uniprot:
- Q9QZD1
- Synonyms:
- chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1);SDF-1 gamma;Sdf1;stromal cell-derived factor 1;stromal cell-derived factor-1 gamma
- Extra Details:
- The stromal cell derived factor 1 (SDF1/CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors. The SDF1/CXCL12 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells. SDF1/CXCL12 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells. Many cancer cells express CXCR4, suggesting that SDF1/CXCL12 plays a role in cancer metastasis. Alternative splicing and differential processing during maturation produce a pair of SDF1/CXCL12 isoforms (SDF1/CXCL12A Alpha and SDF1/CXCL12B Beta) that have different properties and biological activities. Additional isoforms of SDF1/CXCL12 have been reported.
- Shipping Conditions:
- Blue Ice