E-AB-40237
STIL Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- E-AB-40237
- Additional Names:
- DKFZp686O09161,MCPH7,OTTHUMP00000009566,SCL interrupting locus protein,SCL-interrupting locus protein,SCL/TAL1 interrupting locus,SIL,STIL,STIL_HUMAN,TAL 1 interrupting locus protein,TAL-1-interrupting locus protein
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Human SCL-interrupting locus protien
- Uniprot:
- Q15468
- Synonyms:
- MCPH7;SCL-interrupting locus protein;SCL/TAL1 interrupting locus;SIL;TAL-1-interrupting locus protein
- Extra Details:
- This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice