E-AB-40032
AKT1 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- E-AB-40032
- Additional Names:
- AKT,AKT 1,AKT1,MGC99656,PKB,PKB-ALPHA,PRKBA,Protein Kinase B Alpha,Protein kinase B,Proto-oncogene c-Akt,RAC,RAC Alpha,RAC-PK-alpha,RAC-alpha serine/threonine-protein kinase
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse RAC-alpha serine/threonine-protein kinase protein
- Uniprot:
- P31750
- Synonyms:
- Ak;Akt;AKT1 kinase;Akt1m protein;LTR-akt;PK;PKB;PKB alpha;PKB/A;PKB/Akt;PKBalpha;Protein kinase B;Protein kinase B alpha;protein kinase B-alpha;proto-oncogene c-AKT;Rac;RAC-alpha serine/threonine-protein kinase;RAC-PK-alpha;related to A and C kinases;Thymoma viral proto-oncogene;tumor rejection antigen peptide pRLib
- Extra Details:
- The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
- Shipping Conditions:
- Blue Ice