E-AB-31995
MDM2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-31995
- Additional Names:
- ACTFS,Double minute 2 protein,E3 ubiquitin-protein ligase Mdm2,HDMX,Hdm 2,Hdm2,MDM 2,MDM2,MDM2 oncogene E3 ubiquitin protein ligase,Mdm2 p53 E3 ubiquitin protein ligase homolog,Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding
- Application:
- IHC, WB, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human MDM2 around the non-phosphorylation site of Ser166.
- Uniprot:
- Q00987
- Synonyms:
- ACTFS;Double minute 2 protein;double minute 2, human homolog of; p53-binding protein;E3 ubiquitin-protein ligase Mdm2;hdm2;HDMX;LSKB;MDM2 oncogene, E3 ubiquitin protein ligase;MDM2 proto-oncogene, E3 ubiquitin protein ligase;Mdm2, p53 E3 ubiquitin protein ligase homolog;Mdm2, transformed 3T3 cell double minute 2, p53 binding protein;oncoprotein Mdm2;p53-binding protein Mdm2;RING-type E3 ubiquitin transferase Mdm2
- Extra Details:
- This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
- Shipping Conditions:
- Blue Ice