E-AB-31853
JNK1/2/3 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-31853
- Additional Names:
- JNK-46,JNK1,JNK2,MAP kinase 8,MAPK 8,MAPK8,MAPK9,Mi,Mitogen-activated protein kinase 8,PRKM8,PRKM9,SAPK1,SAPK1A,SAPK1C,SAPK1c,Stress-activated protein kinase 1c,Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1
- Application:
- IHC, WB, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human JNK1/2/3 around the non-phosphorylation site of Thr183.
- Uniprot:
- P45983, P45984, P53779
- Synonyms:
- c-Jun kinase 2;c-Jun N-terminal kinase 1;c-Jun N-terminal kinase 2;c-Jun N-terminal kinase 3;JNK;JNK-46;JNK-55;JNK1;JNK1A2;JNK2;JNK21B1/2;JNK2A;JNK2ALPHA;JNK2B;JNK2BETA;JNK3;JNK3 alpha protein kinase;JNK3A;Jun kinase;JUN N-terminal kinase;MAP kinase 10;MAP kinase 8;MAP kinase 9;MAP kinase p49 3F12;MAPK 9;mitogen-activated protein kinase 10;mitogen-activated protein kinase 8;mitogen-activated protein kinase 9;p493F12;p54a;p54aSAPK;p54bSAPK;PRKM10;PRKM8;PRKM9;SAPK;SAPK1;SAPK1a;SAPK1b;SAPK1c;stress activated protein kinase beta;stress-activated protein kinase 1;stress-activated protein kinase 1a;stress-activated protein kinase 1b;stress-activated protein kinase 1c;Stress-activated protein kinase JNK1;stress-activated protein kinase JNK2;stress-activated protein kinase JNK3
- Extra Details:
- c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield ten isoforms through alternative mRNA splicing, including JNK1A Alpha1,JNK1B Beta1, JNK2A Alpha1, JNK2B Beta1 and JNK3A Alpha1, which represent the p46 isoforms, and JNK1A Alpha2, JNK1B Beta2, JNK2A Alpha2, JNK2B Beta2 and JNK3B Beta2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and ransformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38.
- Shipping Conditions:
- Blue Ice