E-AB-31844
JAK2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-31844
- Additional Names:
- JAK 2,JAK-2,JAK2,JTK 10,JTK10,Janus Activating Kinase 2,Janus kinase 2,Janus kinase 2 (a protein tyrosine kinase),OTTHUMP00000043260,THCYT3,Tyrosine protein kinase JAK2,Tyrosine-protein kinase JAK2,kinase Jak2
- Application:
- IHC, WB, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human JAK2 around the non-phosphorylation site of Tyr1007.
- Uniprot:
- O60674
- Synonyms:
- JAK-2;Janus kinase 2;Janus kinase 2 (a protein tyrosine kinase);JTK10;tyrosine-protein kinase JAK2
- Extra Details:
- Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), granulocyte-macrophage colony-stimulating factor (CSF2), thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity). Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
- Shipping Conditions:
- Blue Ice