E-AB-31629
GSK3 beta Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-31629
- Additional Names:
- GSK 3 beta,GSK-3 beta,GSK3B,GSK3beta isoform,Glycogen Synthase Kinase 3 Beta,Glycogen synthase kinase-3 beta,Serine/threonine-protein kinase GSK3B
- Application:
- IHC, WB, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human GSK3B Beta around the non-phosphorylation site of Ser9.
- Uniprot:
- P49841
- Synonyms:
- glycogen synthase kinase-3 beta;GSK-3 beta;serine/threonine-protein kinase GSK3B
- Extra Details:
- Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
- Shipping Conditions:
- Blue Ice