E-AB-31628
GSK3 alpha/beta Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-31628
- Additional Names:
- GSK-3 alpha,GSK-3 beta,GSK3A,GSK3B,Glycogen synthase kinase-3 alpha,Glycogen synthase kinase-3 beta,Serine/threonine-protein kinase GSK3A,Serine/threonine-protein kinase GSK3B
- Application:
- IHC, WB, IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human GSK3A Alpha/B Beta around the non-phosphorylation site of Tyr279/216.
- Uniprot:
- P49840, P49841
- Synonyms:
- glycogen synthase kinase-3 alpha;glycogen synthase kinase-3 beta;GSK-3 alpha;GSK-3 beta;serine/threonine-protein kinase GSK3A;serine/threonine-protein kinase GSK3B
- Extra Details:
- Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3A Alpha and Ser9 of GSK-3B BetaGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.
- Shipping Conditions:
- Blue Ice