E-AB-31399
FAK Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-31399
- Additional Names:
- FADK,FADK 1,FAK related non kinase polypeptide,FAK1,FRNK,Focal adhesion Kinase,Focal adhesion kinase 1,Focal adhesion kinase isoform FAK Del33,Focal adhesion kinase related nonkinase,PPP1R71,Protein phosphatase 1 regulatory subunit 7,p125FAK,pp125FAK
- Application:
- IHC, WB, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human FAK around the non-phosphorylation site of Tyr397.
- Uniprot:
- Q05397
- Synonyms:
- FADK;FADK 1;FAK;FAK-related non-kinase polypeptide;FAK1;focal adhesion kinase 1;focal adhesion kinase-related nonkinase;FRNK;p125FAK;pp125FAK;PPP1R71;protein phosphatase 1 regulatory subunit 71;Protein-tyrosine kinase 2;PTK2 protein tyrosine kinase 2
- Extra Details:
- Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
- Shipping Conditions:
- Blue Ice