E-AB-31372
ERK 1/2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-31372
- Additional Names:
- ERK-1,ERK1,ERT2,Extracellular signal-regulated kinase 1,Insulin-stimulated MAP2 kinase,MAP kinase 3,MAP kinase isoform p44,MAPK 3,MAPK3,Microtubule-associated protein 2 kinase,Mitogen-activated protein kinase 3,PRKM3,p,p44-MAPK
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human ERK 1/2 around the non-phosphorylation site of Thr202.
- Uniprot:
- P27361, P28482
- Synonyms:
- ERK;ERK-1;ERK-2;ERK1;ERK2;ERT1;ERT2;extracellular signal-regulated kinase 1;extracellular signal-regulated kinase 2;extracellular signal-related kinase 1;HS44KDAP;HUMKER1A;insulin-stimulated MAP2 kinase;MAP kinase 1;MAP kinase 2;MAP kinase isoform p42;MAP kinase isoform p44;MAPK 1;MAPK 2;MAPK2;microtubule-associated protein 2 kinase;mitogen-activated protein kinase 1;mitogen-activated protein kinase 2;mitogen-activated protein kinase 3;NS13;p38;p40;p41;p41mapk;p42-MAPK;P42MAPK;p44-ERK1;p44-MAPK;P44ERK1;P44MAPK;PRKM1;PRKM2;PRKM3;protein tyrosine kinase ERK2
- Extra Details:
- Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1, required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
- Shipping Conditions:
- Blue Ice