E-AB-30103
RUNX2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-30103
- Additional Names:
- AML3,Acute myeloid leukemia 3 protein,Alpha subunit 1,CBF alpha 1,CBF-alpha-1,CBFA1,CCD,CCD1,Cleidocranial dysplasia 1,Core binding factor,Core binding factor runt domain alpha subunit 1,Core binding factor subunit alpha 1,Core-binding factor subunit alph
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from the Internal region of human RUNX2.
- Uniprot:
- Q13950
- Synonyms:
- acute myeloid leukemia 3 protein;AML3;CBF-alpha-1;CBFA1;CCD;CCD1;CLCD;Core-binding factor subunit alpha-1;core-binding factor, runt domain, alpha subunit 1;oncogene AML-3;OSF-2;OSF2;osteoblast-specific transcription factor 2;PEA2-alpha A;PEA2aA;PEBP2-alpha A;PEBP2aA;polyomavirus enhancer-binding protein 2 alpha A subunit;runt related transcription factor 2;runt-related transcription factor 2;SL3-3 enhancer factor 1 alpha A subunit;SL3/AKV core-binding factor alpha A subunit
- Extra Details:
- Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.
- Shipping Conditions:
- Blue Ice