Cleaved-CASP3 p17 (D175) Polyclonal Antibody

Size

£106.20

Was £118.00

SKU:: E-AB-30004
Additional Names:: A830040C14Rik,Apopain,CASP-3,CASP3,CC3,CPP-32,CPP32,CPP32B,Casp3a,Caspase 3,Caspase-3 subunit p12,Cysteine p,apoptosis-related cysteine peptidase,apoptosis-related cysteine protease,apoptosis-related cysteine protease a
Application:: IHC, WB, IHC-P, IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
Immunogen:: Synthesized peptide derived from the Internal region of human Caspase-3 p17
Uniprot:: P42574
Synonyms:: apopain;CASP-3;caspase 3, apoptosis-related cysteine peptidase;caspase 3, apoptosis-related cysteine protease;caspase-3;CPP-32;CPP32;CPP32B;cysteine protease CPP32;PARP cleavage protease;procaspase3;protein Yama;SCA-1;SREBP cleavage activity 1
Extra Details:: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.