E-AB-22189
HIF1 bata Monoclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-22189
- Additional Names:
- ARNT,ARNT protein,Aryl hydrocarbon receptor nuclear translocator,Class E basic helix-loop-helix protein 2,Dioxin receptor,Dioxin receptor nuclear translocator,Drnt,HIF 1 beta,HIF 1beta,HIF-1-beta,HIF1-beta,HIF1B,HIF1beta,Hypoxia Inducible Fact,arnT,bHLHe2
- Application:
- IHC, WB, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Recombinant Protein
- Clone:
- 4C5
- Uniprot:
- P27540
- Synonyms:
- aryl hydrocarbon receptor nuclear translocator;bHLHe2;class E basic helix-loop-helix protein 2;dioxin receptor, nuclear translocator;HIF-1-beta;HIF-1beta;HIF1-beta;HIF1B;HIF1BETA;Hypoxia-inducible factor 1-beta;hypoxia-inducible factor 1, beta subunit;TANGO
- Extra Details:
- Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response to hypoxia (1). The HIF1 complex consists of two subunits, HIF-1A Alpha and HIF-1B Beta, which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family (2). HIF1 regulates the transcription of a broad range of genes that facilitate responses to the hypoxic environment, including genes regulating angiogenesis, erythropoiesis, cell cycle, metabolism and apoptosis. The widely expressed HIF-1A Alpha is typically degraded rapidly in normoxic cells by the ubiquitin/proteasomal pathway. Under normoxic conditions, HIF-1A Alpha is proline hydroxylated leading to a conformational change that promotes binding to the von Hippel Lindau protein (VLH) E3 ligase complex, ubiquitination and proteasomal degradation follows (3,4). Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1A Alpha degradation and lead to its stabilization. In addition, HIF-1A Alpha can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway (5-7).HIF-1B Beta is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex (8). Together with AhR, HIF-1B Beta plays an important role in xenobiotics metabolism (8).
- Shipping Conditions:
- Blue Ice