E-AB-22148
NBR1 Monoclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-22148
- Additional Names:
- 1A1 3B,1A13B,B box protein,Cell migration-inducing gene 19 protein,KIAA0049,M17S2,MIG 19,MIG19,Membrane component,Membrane component chromosome 17 surface marker 2,Migration inducing protein,chromosome 17,surface marker 2 (ovarian carcinoma antigen CA125)
- Application:
- IHC, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Recombinant Protein of NBR1
- Clone:
- 4C6
- Uniprot:
- Q14596
- Synonyms:
- 1A1-3B;B-box protein;cell migration-inducing gene 19 protein;IAI3B;M17S2;Membrane component chromosome 17 surface marker 2;membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125);MIG19;migration-inducing protein 19;neighbor of BRCA1 gene 1;Neighbor of BRCA1 gene 1 protein;next to BRCA1 gene 1 protein;Protein 1A1-3B
- Extra Details:
- The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.
- Shipping Conditions:
- Blue Ice