E-AB-20966
Phospho-PI 3 kinase p85 alpha /gamma (Tyr467/199) Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-20966
- Additional Names:
- GRB1,P85A,Phosphatidylinositol 3 kinase,Phosphatidylinositol 3 kinase associated p 85 alpha,Phosphatidylinositol 3 kinase regulatory 1,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,p85,p85 alpha,polypeptide 1 (p85 alpha),regulatory subunit
- Application:
- IHC, WB, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human PI 3-kinase p85/p55 around the phosphorylation site of Tyr467/199
- Uniprot:
- P27986, Q92569
- Synonyms:
- AGM7;GRB1;IMD36;p55;p55-GAMMA;p55PIK;p85;p85-ALPHA;phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma;phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha;phosphatidylinositol 3-kinase regulatory subunit alpha;phosphatidylinositol 3-kinase regulatory subunit gamma;phosphatidylinositol 3-kinase-associated p-85 alpha;phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha);phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma);phosphoinositide-3-kinase regulatory subunit alpha;phosphoinositide-3-kinase, regulatory subunit 1 (alpha);phosphoinositide-3-kinase, regulatory subunit 3 (gamma);PI3-kinase regulatory subunit gamma;PI3-kinase subunit p55-gamma;PI3-kinase subunit p85-alpha;PI3K regulatory subunit alpha;PI3K regulatory subunit gamma;ptdIns-3-kinase regulatory subunit alpha;ptdIns-3-kinase regulatory subunit p55-gamma
- Extra Details:
- The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
- Shipping Conditions:
- Blue Ice