E-AB-20959
Phospho-p70 S6 kinase alpha (Ser447) Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-20959
- Additional Names:
- 70 kDa ribosomal protein S6 kinase 1,KS6B1,P70 S6 Kinase,P70 beta 1,alpha 1,alpha 2,p70 S6 kinase,p70 S6 kinase alpha,p70 S6K,p70 S6K-alpha,p70 S6KA,p70 alpha,p70 ribosomal S6 kinase alpha,p70 ribosomal S6 kinase beta 1,p70(S6,p70(S6K) alpha
- Application:
- IHC, WB, IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human p70 S6 kinase A Alpha around the phosphorylation site of Ser447
- Uniprot:
- P23443
- Synonyms:
- 70 kDa ribosomal protein S6 kinase 1;p70 ribosomal S6 kinase alpha;p70 S6KA;p70-alpha;p70-S6K;p70(S6K)-alpha;PS6K;ribosomal protein S6 kinase beta-1;ribosomal protein S6 kinase I;ribosomal protein S6 kinase, 70kDa, polypeptide 1;S6K;S6K-beta-1;S6K1;serine/threonine kinase 14 alpha;serine/threonine-protein kinase 14A;STK14A
- Extra Details:
- P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
- Shipping Conditions:
- Blue Ice