E-AB-20843
Phospho-CHEK2 (Thr68) Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-20843
- Additional Names:
- CDS 1,CHEK 2,CHK2,CHK2 checkpoint homolog,CHK2 checkpoint homolog (S. pombe),Cds1,Cds1 homolog,Checkpoint kinase 2,Checkpoint like protein CHK2,Chek2,Chk 2,HuCds 1,LFS 2,LFS2,PP1425,RAD 53,RAD53,Rad53 homolog,Ser,Serine/threonine protein kinase Chk2,hCds1
- Application:
- IHC, WB, IHC-P, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human Chk2 around the phosphorylation site of Thr68
- Uniprot:
- O96017
- Synonyms:
- CDS1;cds1 homolog;Checkpoint kinase 2;checkpoint-like protein CHK2;CHK2;CHK2 checkpoint homolog;hCds1;HuCds1;LFS2;PP1425;RAD53;serine/threonine-protein kinase Chk2
- Extra Details:
- Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
- Shipping Conditions:
- Blue Ice