E-AB-20830
Phospho-Catenin beta (Tyr654) Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-20830
- Additional Names:
- 88kDa,Beta catenin,Beta-catenin,CATNB,CHBCAT,CTNB1,CTNNB,CTNNB1,Cadherin associated protein,Catenin (cadherin associated protein),Catenin beta 1,Catenin beta-1,DKFZp686D02253,FLJ25606,FLJ37923,OTTHUMP00000162082,OTTHUMP0000016522,OTTHUMP00000165222,beta 1
- Application:
- IHC, WB, IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human Catenin-B Beta around the phosphorylation site of Tyr654
- Uniprot:
- P35222
- Synonyms:
- armadillo;Beta-catenin;catenin (cadherin-associated protein), beta 1, 88kDa;catenin beta-1;CTNNB;EVR7;MRD19;NEDSDV
- Extra Details:
- Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
- Shipping Conditions:
- Blue Ice