E-AB-19540
HUWE1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-19540
- Additional Names:
- ARF BP1,ARF binding protein 1,ARF-BP1,ARF-binding protein 1,BJ-HCC-24 tumor antigen,E3 ubiquitin protein ligase HUWE1,E3 ubiquitin-protein ligase HUWE1,HECT,HECT UBA and WWE domain containing protein 1,HECT domain protein LASU1,HectH9,Homologous to E6AP c
- Application:
- IHC
- Concentration:
- 0.8 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human HUWE1
- Uniprot:
- Q7Z6Z7
- Synonyms:
- ARF-binding protein 1;ARF-BP1;BJ-HCC-24 tumor antigen;E3 ubiquitin-protein ligase HUWE1;HECT domain protein LASU1;HECT-type E3 ubiquitin transferase HUWE1;HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase;HECT, UBA and WWE domain-containing protein 1;HECTH9;homologous to E6AP carboxyl terminus homologous protein 9;HSPC272;Ib772;large structure of UREB1;LASU1;Mcl-1 ubiquitin ligase E3;MRXST;MULE;upstream regulatory element-binding protein 1;URE-B1;URE-binding protein 1;UREB1
- Extra Details:
- This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.
- Shipping Conditions:
- Blue Ice