E-AB-19279
CUL4A Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-19279
- Additional Names:
- 2810470J21Rik,AW495282,CUL 4A,CUL-4A,CUL4A,Cul4a,Cul4a protein,Cullin-4A,MGC36573,MGC64071
- Application:
- IHC, WB
- Concentration:
- 1.62 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human CUL4A
- Uniprot:
- Q13619
- Synonyms:
- CUL-4A;cullin-4A
- Extra Details:
- Cullin proteins assemble a large number of RING E3 ubiquitin ligases,participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins,CUL4A (87 kDa) and CUL4B(104 kDa),have been identified. The two CUL4 sequences are 83% identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases,DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol,suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2.
- Shipping Conditions:
- Blue Ice