E-AB-19269
CRACR2A Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-19269
- Additional Names:
- CRAC channel regulator 2A,CRACR2A,Calcium release-activated calcium channel regulator 2A,EF hand calcium binding domain 4B,EF hand calcium binding domain containing protein 4B,EF-hand calcium-binding domain-containing protein 4B,EFC4B,EFCAB 4B,Efcab4b,FLJ
- Application:
- IHC
- Concentration:
- 0.84 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human CRACR2A
- Uniprot:
- Q9BSW2
- Synonyms:
- Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A;calcium release-activated calcium channel regulator 2A;Calcium release-activated channel regulator 2A;CRAC channel regulator 2A;CRAC regulator 2A;EF-hand calcium binding domain 4B;EF-hand calcium-binding domain-containing protein 4B;EFCAB4B;RAB46;ras-related protein Rab-46
- Extra Details:
- Ca2+-binding protein that plays a key role in store-operated Ca2+ entry (SOCE) in T-cells by regulating CRAC channel activation.Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration.It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1.Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
- Shipping Conditions:
- Blue Ice