E-AB-19264
SAV1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-19264
- Additional Names:
- Drosophila, homolog of,1700040G09Rik,45 kDa WW domain protein,Protein salvador homolog 1,SAV,SAV 1,SAV1,Salvador,Salvador homolog 1,WW 45,WW domain containin,hWW 45,hWW45,salvador family WW domain containing protein 1,salvador homolog 1 (Drosophila)
- Application:
- IHC
- Concentration:
- 1.32 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human SAV1
- Uniprot:
- Q9H4B6
- Synonyms:
- 1700040G09Rik;45 kDa WW domain protein;hWW45;protein salvador homolog 1;salvador homolog 1;SAV;WW domain-containing adaptor 45;WW45;WWP4
- Extra Details:
- WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
- Shipping Conditions:
- Blue Ice