E-AB-19075
CBFA2T2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-19075
- Additional Names:
- alpha subunit 2, runt domain,AML1 MTG8,Core binding factor runt domain alpha subunit 2 translocated to 2,DKFZp313F2116,EHT,ETO homolog on chromosome 20,ETO homologous on chromosome 20,MTG 8 like protein,MTG 8 related protein 1,cbfa2t2,core-binding factor
- Application:
- WB
- Concentration:
- 1.26 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human CBFA2T2
- Uniprot:
- O43439
- Synonyms:
- CBFA2/RUNX1 translocation partner 2;core-binding factor, runt domain, alpha subunit 2; translocated to, 2;EHT;ETO homolog on chromosome 20;ETO homologous on chromosome 20;MTG8-like protein;MTG8-related protein 1;MTGR1;myeloid translocation gene-related protein 1;myeloid translocation-related protein 1;p85;protein CBFA2T2;ZMYND3
- Extra Details:
- In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
- Shipping Conditions:
- Blue Ice