E-AB-19035
IFT57 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-19035
- Additional Names:
- CDNA FLJ10147 fis clone HEMBA1003369,DERP 8,DERP8,Dermal papilla derived protein 8,Dermal papilla-derived protein 8,ESRRBL1 protein,Esrrbl 1,Esrrbl1,Estrogen related receptor beta like 1,Estrogen related receptor beta like protein 1,Estrogen-related recep
- Application:
- IHC
- Concentration:
- 1.5 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human IFT57
- Uniprot:
- Q9NWB7
- Synonyms:
- dermal papilla-derived protein 8;ESRRBL1;estrogen-related receptor beta like 1;estrogen-related receptor beta-like protein 1;HIP1 protein interactor;HIP1-interacting protein;HIPPI;huntingtin interacting protein-1 interacting protein;intraflagellar transport 57 homolog;intraflagellar transport protein 57 homolog;MHS4R2;OFD18
- Extra Details:
- Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.
- Shipping Conditions:
- Blue Ice