E-AB-18915
NIPBL Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-18915
- Additional Names:
- CDLS,Colon tumor susceptibility 2,DKFZp434L1319,Delangin,FLJ11203,FLJ12597,FLJ13354,FLJ13648,FLJ44854,IDN 3,IDN 3 protein,IDN 3 protein isoform A,IDN 3 protein isoform B,IDN 3B,IDN3 B,IDN3 protein,IDN3 protein isoform A,IDN3 protein isoform B,IDN3B,Mis 4
- Application:
- IHC
- Concentration:
- 0.9 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human NIPBL
- Uniprot:
- Q6KC79
- Synonyms:
- CDLS;CDLS1;delangin;IDN3;IDN3-B;Nipped-B homolog;nipped-B-like protein;Scc2;SCC2 homolog;sister chromatid cohesion 2 homolog
- Extra Details:
- This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice