E-AB-18906
JPT1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-18906
- Additional Names:
- ARM2,Androgen regulated protein 2,Androgen-regulated protein 2,HN1,HN1A,Hematological and neurological expressed 1,Hematological and neurological expressed 1 protein
- Application:
- IHC
- Concentration:
- 0.6 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human JPT1
- Uniprot:
- Q9UK76
- Synonyms:
- androgen-regulated protein 2;ARM2;hematological and neurological expressed 1 protein;HN1;HN1A;jupiter microtubule associated homolog 1
- Extra Details:
- Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).
- Shipping Conditions:
- Blue Ice