E-AB-18859
NGEF Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-18859
- Additional Names:
- neuronal,ARHGEF27,EPHEXIN,Eph receptor-interacting exchange protein,Eph-interacting exchange protein,Ephexin-1,Guanine nucleotide exchange factor,NGEF,Neuronal guanine nucleotide exchange factor,Ngef
- Application:
- IHC
- Concentration:
- 0.6 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human NGEF
- Uniprot:
- Q8N5V2
- Synonyms:
- ARHGEF27;eph-interacting exchange protein;EPHEXIN;ephexin-1;ephexin1;Neuronal guanine nucleotide exchange factor
- Extra Details:
- Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
- Shipping Conditions:
- Blue Ice