E-AB-18760
C9orf116 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-18760
- Additional Names:
- C9orf116,CI116,Pierce 1,UPF0691 protein C9orf116
- Application:
- IHC
- Concentration:
- 0.96 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human C9orf116
- Uniprot:
- Q5BN46
- Synonyms:
- p53-induced expression 1 in Rb-/- cells;p53-induced expression 1 in Rba^'/a^' cells;p53-induced expression in RB-null cells protein 1;pierce 1;PIERCE1;RbEST47;UPF0691 protein C9orf116
- Extra Details:
- C9orf116, also known as PIERCE1. PIERCE1 is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.
- Shipping Conditions:
- Blue Ice