HLA-DRB5 Polyclonal Antibody

Size

£106.20

Was £118.00

SKU:: E-AB-18660
Additional Names:: DR 9,DR beta 5,DR beta 5 chain,DR beta-5,DR beta5,DR2 beta 2,DR2-beta-2,DR9,DRB5,Dw2,FLJ76359,HLA cla,HLA class II histocompatibility antigen,HLA class II histocompatibility antigen DR beta 5 chain,HLA class II histocompatibility antigen DRB1-9 beta chain
Application:: IHC
Concentration:: 1.62 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Fusion protein of human HLA-DRB5
Uniprot:: Q30154
Synonyms:: DR beta-5;DR2-beta-2;Dw2;HLA class II histocompatibility antigen, DR-5 beta chain;HLA-DRB5*;major histocompatibility complex, class II, DR beta 5;MHC class II antigen DRB5
Extra Details:: HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Shipping Conditions:: Blue Ice