E-AB-17857
PCDHGB5 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-17857
- Additional Names:
- PCDH gamma B5,PCDH-GAMMA-B5,PCDHGB 5,Protocadherin gamma B5,Protocadherin gamma subfamily B 5
- Application:
- IHC
- Concentration:
- 1.4 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human PCDHGB5
- Uniprot:
- Q9Y5G0
- Synonyms:
- PCDH-GAMMA-B5;protocadherin gamma-B5
- Extra Details:
- This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
- Shipping Conditions:
- Blue Ice