E-AB-17810
CARD16 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-17810
- Additional Names:
- member 16,CAR16,CARD only domain-containing protein 1,CARD only protein ,CARD16,COP,COP1,Caspase recruitment domain family,Caspase recruitment domain-containing protein 16,Caspase-1 dominant-negative inhibitor pseudo-ICE ,Caspase-1 inhibitor COP,Pseudo i
- Application:
- IHC, WB
- Concentration:
- 1.1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human CARD16
- Uniprot:
- Q5EG05
- Synonyms:
- CARD only domain-containing protein 1;CARD only protein;CARD-only protein 1;caspase recruitment domain-containing protein 16;caspase recruitment domain-only protein 1;caspase-1 dominant-negative inhibitor pseudo-ICE;caspase-1 inhibitor COP;COP;COP1;LLID-114769;pseudo interleukin-1 beta converting enzyme;pseudo interleukin-1beta converting enzyme;PSEUDO-ICE;pseudo-IL1B-converting enzyme
- Extra Details:
- Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
- Shipping Conditions:
- Blue Ice