E-AB-17757
CACNA2D2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-17757
- Additional Names:
- Alpha 2 delta calcium channel subunit,CA2D2,CACNA2D,Cacna2d2,Calcium channel,Calcium voltage gated channel auxiliary subunit alpha2delta 2,Gene 26,alpha 2/delta subunit 2,alpha 2/delta subunit 2 gene 26,voltage-dependent
- Application:
- IHC
- Concentration:
- 0.7 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human CACNA2D2
- Uniprot:
- Q9NY47
- Synonyms:
- alpha 2 delta calcium channel subunit;CACNA2D;calcium channel, voltage-dependent, alpha 2/delta subunit 2;CASVDD;gene 26;voltage-dependent calcium channel subunit alpha-2/delta-2;voltage-gated calcium channel subunit alpha-2/delta-2
- Extra Details:
- Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Shipping Conditions:
- Blue Ice