E-AB-17743
C14orf169 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-17743
- Additional Names:
- 60S ribosomal protein L8 histidine hydroxylase,C14orf169,Chromosome 14 open reading frame 169 ,Histone lysine demethylase NO66,Hypothetical protein FLJ21802,Lysine-specific demethylase NO66,MAPJD,MYC associated protein with JmjC domain,NO66,Nu,hsNO66
- Application:
- IHC
- Concentration:
- 0.8 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human C14orf169
- Uniprot:
- Q9H6W3
- Synonyms:
- 60S ribosomal protein L8 histidine hydroxylase;bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66;C14orf169;histone lysine demethylase NO66;hsNO66;JMJD9;lysine-specific demethylase NO66;MAPJD;MYC-associated protein with JmjC domain;NO66;nucleolar protein 66;ribosomal oxygenase 1;ribosomal oxygenase NO66;ROX;up-regulated in lung cancer 2;URLC2
- Extra Details:
- Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
- Shipping Conditions:
- Blue Ice