E-AB-17737
CDC123 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-17737
- Additional Names:
- C10orf7,CD123,CDC123,Cell division cycle 123,Cell division cycle 123 homolog,Cell division cycle protein 123 homolog,D123,HT 1080,HT-1080,PZ32,Protein D123
- Application:
- WB
- Concentration:
- 0.9 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human CDC123
- Uniprot:
- O75794
- Synonyms:
- C10orf7;cell division cycle 123 homolog;cell division cycle protein 123 homolog;D123;HT-1080;PZ32
- Extra Details:
- The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.
- Shipping Conditions:
- Blue Ice