E-AB-17495
TXNIP Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-17495
- Additional Names:
- EST01027,HHCPA78,THIF,VDUP1
- Application:
- IHC
- Concentration:
- 0.9 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human TXNIP
- Uniprot:
- Q9H3M7
- Synonyms:
- ARRDC6;EST01027;HHCPA78;THIF;thioredoxin binding protein 2;Thioredoxin-binding protein 2;thioredoxin-interacting protein;upregulated by 1,25-dihydroxyvitamin D-3;VDUP1;vitamin D3 up-regulated protein 1
- Extra Details:
- May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
- Shipping Conditions:
- Blue Ice