E-AB-17482
TTI1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-17482
- Additional Names:
- KIAA0406,smg-10
- Application:
- IHC
- Concentration:
- 1.2 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human TTI1
- Uniprot:
- O43156
- Synonyms:
- KIAA0406;Protein SMG10;smg-10;smg-10 homolog, nonsense mediated mRNA decay factor;Tel two interacting protein 1;TEL2-interacting protein 1 homolog;TELO2-interacting protein 1 homolog
- Extra Details:
- Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
- Shipping Conditions:
- Blue Ice