E-AB-17390
GAD1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-17390
- Additional Names:
- 67 kDa glutamic acid decarboxylase,67kDa),CPSQ1,DCE1,EC 4.1.1.15,FLJ45882,GAD,GAD 67,GAD-67,GAD1,Glutamate decarboxy,Glutamate decarboxylase 1,Glutamate decarboxylase 1 (brain,Glutamate decarboxylase 1 brain 67kD,Glutamate decarboxylase 1 brain 67kDa
- Application:
- IHC, WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human GAD1
- Uniprot:
- Q99259
- Synonyms:
- 67 kDa glutamic acid decarboxylase;CPSQ1;DEE89;GAD;GAD-67;glutamate decarboxylase 1;glutamate decarboxylase 1 (brain, 67kDa);Glutamate decarboxylase 67 kDa isoform;SCP
- Extra Details:
- This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes.The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid.A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes.This gene may also play a role in the stiff man syndrome.Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures.Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
- Shipping Conditions:
- Blue Ice