E-AB-16651
PNOC Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-16651
- Additional Names:
- N/OFQ,N23K,N23K/N27K,Nociceptin,Npnc1,OFQ,OFQ/N,Orphanin FQ,Orphanin FQ2,PNOC,PPNOC,Pnoc,Propronociceptin,included,nocistatin,ppN/OFQ,pre-pro-N/OFQ,prepronociceptin,pronociceptin
- Application:
- IHC
- Concentration:
- 0.4 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human PNOC
- Uniprot:
- Q13519
- Synonyms:
- N/OFQ;nociceptin;nocistatin;NOP;OFQ;orphanin FQ;ppN/OFQ;PPNOC;pre-pro-N/OFQ;prepronociceptin;pronociceptin
- Extra Details:
- Nociception, a pain response mechanism, occurs in response to stimuli that threaten the integrity of an organism. The first synapses produced as a result of the initiation of nociception are modulated by excitatory amino acids (glutamate and aspartate) and many peptides (substance P, CGRP, CCK, endogenous opioids). Nociceptin (also designated orphanin FQ) is a neuronal peptide that is similar to opioid peptides. Nociceptin activates KOR-3 (kappa-type opioid receptor, also designated ORL1), a G protein-coupled receptor. Although similar to dynorphin A, a kappa opioid peptide, nociceptin functions to make animals hyperreactive to nociceptive stimulations. Nociceptin is also involved in locomotor behavior and may be involved in the modulation of synaptic plasticity in learning and memory.
- Shipping Conditions:
- Blue Ice