E-AB-16413
ERN2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-16413
- Additional Names:
- IRE1-BETA,IRE1b
- Application:
- IHC
- Concentration:
- 1.1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human ERN2
- Uniprot:
- Q76MJ5
- Synonyms:
- endoplasmic reticulum to nucleus signalling 2;Endoplasmic reticulum-to-nucleus signaling 2;ER to nucleus signalling 2;hIRE2p;inositol-requiring 1 beta;inositol-requiring protein 2;IRE1 beta;IRE1-BETA;IRE1, S. cerevisiae, homolog of;IRE1b;IRE2p;serine/threonine-protein kinase/endoribonuclease IRE2
- Extra Details:
- The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1A Alpha and IRE1B Beta are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
- Shipping Conditions:
- Blue Ice