DEFA4 Polyclonal Antibody

Size

£106.20

Was £118.00

SKU:: E-AB-16384
Additional Names:: DEF4,HNP-4,HP-4,HP4
Application:: IHC
Concentration:: 0.9 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Synthetic peptide of human DEFA4
Uniprot:: P12838
Synonyms:: corticostatin;DEF4;Defensin, alpha 4;defensin, alpha 4, corticostatin;defensin, alpha 4, preproprotein;HNP-4;HP-4;HP4;neutrophil defensin 4
Extra Details:: Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils, it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.