E-AB-16049
SCN1A Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-16049
- Additional Names:
- EIEE6,FEB3,FEB3A,FHM3,GEFS+2,GEFSP2,HBSC I,HBSCI,NAC1,Nav 1.1,RBI,SCN1,SCN1A,SMEI,Scn1a,Sodiu,Sodium channel protein brain I alpha subunit,Sodium channel protein brain I subunit alpha,Sodium channel protein type 1 subunit alpha,brain sodium channel type I
- Application:
- IHC
- Concentration:
- 0.5 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/13A
- Uniprot:
- P35498
- Synonyms:
- DEE6;DEE6A;DEE6B;DRVT;EIEE6;FEB3;FEB3A;FHM3;GEFSP2;HBSCI;NAC1;Nav1.1;SCN1;SMEI;Sodium channel protein brain I subunit alpha;sodium channel protein type 1 subunit alpha;sodium channel protein type I subunit alpha;sodium channel protein, brain I alpha subunit;sodium channel voltage gated type 1 alpha subunit;sodium channel, voltage-gated, type I, alpha polypeptide;sodium channel, voltage-gated, type I, alpha subunit;voltage-gated sodium channel subunit alpha Nav1.1
- Extra Details:
- Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops, each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
- Shipping Conditions:
- Blue Ice