E-AB-16022
PTAFR Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-16022
- Additional Names:
- OTTHUMP00000004041,OTTMUSP00000010350,PAF R,PAF receptor,PAF-R,PAFr,PTAFR,Platelet activating factor receptor,Platelet-activating factor receptor,RP23-470B20.1
- Application:
- IHC
- Concentration:
- 0.5 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human PTAFR
- Uniprot:
- P25105
- Synonyms:
- PAF-R;PAFR;platelet-activating factor receptor
- Extra Details:
- This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice