E-AB-15853
SMAD7 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-15853
- Additional Names:
- CRCS3,FLJ16482,MAD,MAD (mothers against decapentaplegic Drosophila) homolog 7,MAD homolog 8,MAD mothers against decapentaplegic homolog 7,MADH 7,MADH 8,MADH6,MADH8,Mad homolog 7,Mother,Mothers Against Decapentaplegic Drosophila Homolog of 6,hSMAD 7,hSMAD7
- Application:
- IHC
- Concentration:
- 0.4 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human SMAD7
- Uniprot:
- O15105
- Synonyms:
- CRCS3;hSMAD7;MAD (mothers against decapentaplegic, Drosophila) homolog 7;MAD homolog 8;MADH7;MADH8;mothers against decapentaplegic homolog 7;Mothers against decapentaplegic homolog 8;Mothers against decapentaplegic, drosophila, homolog of, 7;mothers against DPP homolog 8;SMAD family member 7;SMAD, mothers against DPP homolog 7
- Extra Details:
- The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice