E-AB-15716
HMGB1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-15716
- Additional Names:
- Amphoterin,Chromosomal protein,DKFZp686A04236,HMG-1,HMG1,HMG3,HMGB 1,HMGB1,High mobility group 1,High mobility group box 1,High mobility group protein 1,High mobility group protein B1,high-mobility group (nonhistone chromosomal) protein 1,nonhistone
- Application:
- IHC, WB
- Concentration:
- 0.3 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human HMGB1
- Uniprot:
- P09429
- Synonyms:
- Amphoterin;High mobility group protein 1;high mobility group protein B1;high-mobility group (nonhistone chromosomal) protein 1;HMG-1;HMG1;HMG3;SBP-1;Sulfoglucuronyl carbohydrate binding protein
- Extra Details:
- High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin.Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix.HMG proteins synergize with Oct-2, members of the NF B family, ATF-2 and c-Jun to activate transcription.Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein.Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes.HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
- Shipping Conditions:
- Blue Ice