E-AB-15608
SLC1A6 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-15608
- Additional Names:
- Excitatory amino acid transporter 4,High affinity neuronal glutamate transporter,MGC33092,MGC43671,Sodium dependent glutamate/aspartate transporter,Solute carrier family 1 (high affinity aspartate/glutamate transporter) member 6,Solute carrier family 1 me
- Application:
- IHC, WB
- Concentration:
- 0.4 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human SLC1A6
- Uniprot:
- P48664
- Synonyms:
- EAAT4;excitatory amino acid transporter 4;sodium-dependent glutamate/aspartate transporter;solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6;Solute carrier family 1 member 6
- Extra Details:
- Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering.
- Shipping Conditions:
- Blue Ice