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CK-6A/B/C Polyclonal Antibody

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E-AB-15555

CK-6A/B/C Polyclonal Antibody

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£106.20

Was £118.00

SKU:
E-AB-15555
Additional Names:
CK-6B,CK6A,CK6B,CK6C,CK6D,K6A,K6B,K6C,K6D,K6E,KRT6C,KRT6D,KRT6E,KRTL1,PC2
Application:
IHC
Concentration:
0.4 mg/ml
Purification:
Affinity Purified
Storage Conditions:
-20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Host:
Rabbit
Reactivities:
Human, Mouse
Buffer:
Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:
Synthetic peptide of human KRT6A/KRT6B/KRT6C
Uniprot:
P02538, P04259, P48668
Synonyms:
CK-6B;CK-6C;CK-6E;CK6A;CK6B;CK6C;CK6D;cytokeratin 6A;cytokeratin 6B;cytokeratin 6C;cytokeratin 6D;Cytokeratin-6A;Cytokeratin-6B;cytokeratin-6C;Cytokeratin-6D;cytokeratin-6E;K6A;K6B;K6C;K6D;K6E;keratin 6A, , type II;keratin 6A, type II;keratin 6B, type II;keratin 6C, type II;keratin 6E;keratin K6h;Keratin-6A;Keratin-6B;Keratin-6C;keratin-like 1 (a type II keratin sequence);keratin, epidermal type II, K6A;keratin, epidermal, type II, K6B;keratin, type II cytoskeletal 6A;keratin, type II cytoskeletal 6B;keratin, type II cytoskeletal 6C;KRT6C;KRT6D;KRT6E;KRTL1;PC2;PC3;PC4;PPKNEFD;type-II keratin Kb10;type-II keratin Kb12;type-II keratin Kb6
Extra Details:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified, the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Shipping Conditions:
Blue Ice