E-AB-15523
BBC3 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-15523
- Additional Names:
- BBC 3,BBC3,BCL 2 binding component 3,BCL2 binding component 3,Bbc3,Bcl-2-binding component 3,JFY 1,JFY-1,JFY1,PUMA alpha,PUMA/JFY1,p53 Upregulated Modulator of Apoptosis,p53 up regulated modulator of apoptosis,p53 up-regulated modulator of apoptosis
- Application:
- WB
- Concentration:
- 0.9 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human BBC3
- Uniprot:
- Q9BXH1
- Synonyms:
- bcl-2-binding component 3;JFY-1;JFY1;p53 up-regulated modulator of apoptosis;p53-upregulated modulator of apoptosis;PUMA
- Extra Details:
- This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice