E-AB-15380
DHCR24 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-15380
- Additional Names:
- 24 dehydrocholesterol reductase,24-dehydrocholesterol reductase,3 beta hydroxysterol delta 24 reductase,3-beta-hydroxysterol delta-24-reductase,DCE,DHC24,Delta(24)-sterol reductase,Desmosterol to cholesterol enzyme,Dhcr24,Diminuto dwarf1 homolog,Diminuto
- Application:
- IHC
- Concentration:
- 0.7 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human DHCR24
- Uniprot:
- Q15392
- Synonyms:
- 24-dehydrocholesterol reductase;3 beta-hydroxysterol delta 24-reductase;3-beta-hydroxysterol Delta-24-reductase;DCE;delta(24)-sterol reductase;desmosterol-to-cholesterol enzyme;diminuto/dwarf1 homolog;Nbla03646;seladin 1;seladin-1;SELADIN1;selective AD indicator 1
- Extra Details:
- This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
- Shipping Conditions:
- Blue Ice