E-AB-15225
PLEKHG6 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-15225
- Additional Names:
- FLJ10665,MGC126315,MGC126353,MGC126354,Myosin interacting guanine nucleotide exchange factor,PH domain containing family G member 6,Pleckstrin homology domain containing family G (with RhoGef domain) member 6,Pleckstrin homology domain-containing family G
- Application:
- WB
- Concentration:
- 0.1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human PLEKHG6
- Uniprot:
- Q3KR16
- Synonyms:
- MyoGEF;myosin II interacting GEF;myosin interacting guanine nucleotide exchange factor;Myosin-interacting guanine nucleotide exchange factor;PH domain-containing family G member 6;pleckstrin homology domain containing, family G (with RhoGef domain) member 6;pleckstrin homology domain-containing family G member 6
- Extra Details:
- PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
- Shipping Conditions:
- Blue Ice