E-AB-15186
TAB1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-15186
- Additional Names:
- 2310012M03Rik,3'-Tab1,MAP3K7IP 1,MAP3K7IP1,MGC57664,Mitogen activated protein kinase kinase kinase 7 interacting protein 1,Mitogen-activated protein kinase kinase kinase 7-interacting protein 1,TAB 1,TAB1,TAK1 binding protein 1,TAK1-binding protein 1
- Application:
- IHC
- Concentration:
- 0.2 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human TAB1
- Uniprot:
- Q15750
- Synonyms:
- 3'-Tab1;MAP3K7IP1;mitogen-activated protein kinase kinase kinase 7-interacting protein 1;TAK1-binding protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;TGF-beta-activated kinase 1-binding protein 1;transforming growth factor beta-activated kinase-binding protein 1
- Extra Details:
- The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.
- Shipping Conditions:
- Blue Ice